Glossary entry (derived from question below)
Italian term or phrase:
acido pivalico
English translation:
pivalic acid
Added to glossary by
texjax DDS PhD
Jul 13, 2009 19:53
14 yrs ago
Italian term
Italy
translating meaning, not just words
Native in: English 
Works in: English to Italian, Italian to English, English
acido rivalico
Italian to English
Medical
Medical: Pharmaceuticals
"Metaboliti tossici possono formarsi anche in seguito al trattamento con alcuni farmaci (es: acido valproico, antibiotici coniugati con l’acido rivalico). "
All I can find on the internet is pivalic acid. Can anyone suggest an answer with some references to back it up? TIA.
All I can find on the internet is pivalic acid. Can anyone suggest an answer with some references to back it up? TIA.
Proposed translations
(English)
| 3 +5 | pivalic acid |
texjax DDS PhD
|
References
| carnitine datasheet |
Dr Lofthouse
|
Change log
Jul 16, 2009 01:48: texjax DDS PhD Created KOG entry
Proposed translations
+5
1 hr
texjax DDS PhD
Native in Italian
Specializes in field
Degree + PhD in Dentistry, ATA-Certified
Native in: Italian
Works in: English to Italian, Italian to English, Italian
Related KudoZ points
:
202
Selected
pivalic acid
Typo for pivalic acid/pivalate, which may cause carnitine deficiency.
I have no time to read all the references, but I believe we are on the right track.
Sodium pivalate, a compound conjugated to carnitine and excreted in the urine was used to induce a secondary carnitine deficiency. ...
jn.nutrition.org/cgi/content/abstract/121/12/2029 - Similar
by PB Bianchi - 1991 - Cited by 19 - Related articles - All 4 versions
http://www.google.com/search?hl=en&ie=ISO-8859-1&q="secondar...
Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA is the major route of pivalate elimination. Because the total body carnitine pool is limited and can only slowly be replenished through normal diet or biosynthesis, treatment with large doses of pivalate prodrugs may deplete tissue carnitine content.
http://pharmrev.aspetjournals.org/cgi/content/full/54/4/589
http://www.chemexper.com/chemicals/supplier/cas/75-98-9.html
File Format: PDF/Adobe Acrobat - View as HTML
Trattamento con Benzoato, Acido Pivalico, or. Acido Valproico. . Deficienza di Assorbimento di Carnitina. . Deficienza di Biotinidasi ...
www.isf-stem.com/documenti/06-080128-Patologie screening.pd... - Similar
http://en.wikipedia.org/wiki/Pivalic_acid
I have no time to read all the references, but I believe we are on the right track.
Sodium pivalate, a compound conjugated to carnitine and excreted in the urine was used to induce a secondary carnitine deficiency. ...
jn.nutrition.org/cgi/content/abstract/121/12/2029 - Similar
by PB Bianchi - 1991 - Cited by 19 - Related articles - All 4 versions
http://www.google.com/search?hl=en&ie=ISO-8859-1&q="secondar...
Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA is the major route of pivalate elimination. Because the total body carnitine pool is limited and can only slowly be replenished through normal diet or biosynthesis, treatment with large doses of pivalate prodrugs may deplete tissue carnitine content.
http://pharmrev.aspetjournals.org/cgi/content/full/54/4/589
http://www.chemexper.com/chemicals/supplier/cas/75-98-9.html
File Format: PDF/Adobe Acrobat - View as HTML
Trattamento con Benzoato, Acido Pivalico, or. Acido Valproico. . Deficienza di Assorbimento di Carnitina. . Deficienza di Biotinidasi ...
www.isf-stem.com/documenti/06-080128-Patologie screening.pd... - Similar
http://en.wikipedia.org/wiki/Pivalic_acid
Note from asker:
| Thanks, this is exactly what I needed - the funny thing is that there are several Italian links to acido rivalico, such as this one www.bioinst.com/pdf/istruzioni_raccolta_stepone.pdf as well as to acido pivalico. |
Peer comment(s):
| agree |
Lirka
: most probably
39 mins
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Thank you Lirka
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| agree |
Zareh Darakjian Ph.D.
: Yes. Antibiotics that are conjugated with pivalic acid release the latter, I believe in the intestinal wall... // Nice to see you too Doctor!
46 mins
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Thanks Zareh, nice to see you here
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| agree |
Dr Lofthouse
: agree - its a typo for 'pivalico' - refers to pivaloyl antibiotics like pivampicillin'
3 hrs
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Grazie Dr Loft :)
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| agree |
Panagiotis Andrias (X)
10 hrs
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Thanks
|
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| agree |
Lionel_M (X)
13 hrs
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Grazie 1000 Lionel
|
4 KudoZ points awarded for this answer.
Comment: "thanks!"
Reference comments
4 hrs
Dr Lofthouse
France
France
Native in Italian
&
English
Works in field
France
When Accuracy Counts -
Native in: English 
, Italian
Works in: Italian to English, German to English, French to English, and 10 more.
Related KudoZ points
:
28
Reference:
carnitine datasheet
mentions 'pivaloyl antibiotics'
Discussion
Nutritional L-carnitine deficiency has not been shown to occur in the ... drugs (including pivalic acid-containing prodrugs, valproic acid, cisplatin, ...
books.google.gr/books?isbn=0824755049...